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| Ethyl 3-(pyridin-2-ylamino)propanoate Basic information |
| Ethyl 3-(pyridin-2-ylamino)propanoate Chemical Properties |
Melting point | 48-50°C | Boiling point | 125°C/0.2mmHg(lit.) | density | 1.131±0.06 g/cm3(Predicted) | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | solubility | DMSO, Methanol | form | Solid | pka | 6.26±0.10(Predicted) | color | White | InChI | InChI=1S/C10H14N2O2/c1-2-14-10(13)6-8-12-9-5-3-4-7-11-9/h3-5,7H,2,6,8H2,1H3,(H,11,12) | InChIKey | UITNIDFEANEWPC-UHFFFAOYSA-N | SMILES | C(OCC)(=O)CCNC1C=CC=CN=1 | LogP | 1.54 at 22℃ and pH6 |
| Ethyl 3-(pyridin-2-ylamino)propanoate Usage And Synthesis |
Chemical Properties | White Solid | Uses | Ethyl 3-(2-Pyridylamino)propanoate is an intermediate used in the synthesis of Dabigatran etexilate, as thrombin inhibitors. Ethyl Ester form of P993315. | Uses | Dabigatran etexilate intermediate | Synthesis | A method for preparing Ethyl 3-(pyridin-2-ylamino)propanoate comprises the following steps: using 2-aminopyridine and ethyl acrylate as raw materials, using anhydrous ethanol as a solvent, using trifluoromethanesulfonic acid as a catalyst, and heating in an oil bath to control the temperature at 120 to 160° C. for a catalytic reaction for 16 to 20 hours under nitrogen protection. The obtained reaction solution is washed with petroleum ether at a temperature of 35 to 40° C. and a pressure of 0.09 to 0.1 MPa, then concentrated under reduced pressure, and then washed with petroleum ether/ethyl acetate and recrystallized to obtain white flaky crystals of Ethyl 3-(pyridin-2-ylamino)propanoate. |
| Ethyl 3-(pyridin-2-ylamino)propanoate Preparation Products And Raw materials |
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