- Pamidronic acid
-
- $1.00 / 1KG
-
2021-09-29
- CAS:40391-99-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 10kg/month
|
| | Pamidronic acid Basic information |
| | Pamidronic acid Chemical Properties |
| Melting point | 226-228°C | | Boiling point | 658.7±65.0 °C(Predicted) | | density | 1.998±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Methanol (Very Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated) | | pka | 1.44±0.10(Predicted) | | form | Solid | | color | Light Brown to Beige | | Stability: | Hygroscopic |
| | Pamidronic acid Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Aredia,Novartis,India | | Uses | A biphosphonate bone resorption inhibitor. | | Uses | anticancer | | Definition | ChEBI: Pamidronate is a phosphonoacetic acid. | | Manufacturing Process | For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water. | | Brand name | Rescriptor (Agouron). | | Therapeutic Function | Bone resorption suppressant |
| | Pamidronic acid Preparation Products And Raw materials |
|