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| Products Intro: |
CAS:144-75-2
Purity:98%
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Aldesulfone Sodium manufacturers
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| | Aldesulfone Sodium Basic information |
| Product Name: | Aldesulfone Sodium | | Synonyms: | Novotrone;Sulfonylbis(p-phenyleneimino)bis(methanesulfinic acid)disodium salt;NSC 27222;SodiuM aldesulphone;SodiuM sulfoxone;Adesulfone Sodium;Aldesulfone Sodium;DISODIUM DIFORMALDEHYDESULFOXYLATE | | CAS: | 144-75-2 | | MF: | C14H14N2Na2O6S3 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 144-75-2.mol |  |
| | Aldesulfone Sodium Chemical Properties |
| Melting point | 263-265 °C (decomp) | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White | | Stability: | Stable. Incompatible with strong oxidizing agents. |
| Toxicity | LD50 oral in mouse: 10gm/kg |
| | Aldesulfone Sodium Usage And Synthesis |
| Originator | Diasone Sodium,Abbott,US,1947 | | Uses | Sodium Sulfoxone is used in tuberculosis therapy along with Streptomycin (S687500). | | Manufacturing Process | About 20 grams of diamino diphenyl sulfone is dissolved in about 500 cc of
ethyl alcohol (3A made up of 5 parts methyl alcohol and 100 parts of ethyl
alcohol) by placing the ingredients in a flask provided with a reflux condenser
and warming over a water bath. About 24 grams of pure grade, very finely
powdered (40 to 60 mesh) sodium formaldehyde sulfoxylate is then rapidly
added to the alcohol solution of diamino diphenyl sulfone and the mixture
refluxed in the usual manner. It was found that the mixture should be refluxed
for a total of 5 hours and that a precipitate starts to form near the 3 hour
period. The reaction mixture is then cooled to 15°C and kept at this
temperature for about 1 hour. The precipitate formed in the filtrate is filtered
off rapidly and drained as much as possible to remove mother liquor and then
washed with small amounts of cold alcohol. The solid product is immediately
placed in a desiccator and dried over sulfuric acid for about 20 hours. | | Therapeutic Function | Antibacterial (leprostatic) |
| | Aldesulfone Sodium Preparation Products And Raw materials |
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