1-Benzyl-3-ethoxycarbonyl-4-piperidone manufacturers
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| | 1-Benzyl-3-ethoxycarbonyl-4-piperidone Basic information | | Synthesis |
| Product Name: | 1-Benzyl-3-ethoxycarbonyl-4-piperidone | | Synonyms: | 1-Benzyl-3-carbethoxy-4-piperidone;ethyl 1-benzyl-4-oxopiperidine-3-carboxylate;Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate(HCl ForM);1-(benzyl)-4-keto-nipecotic acid ethyl ester;4-oxo-1-(phenylmethyl)-3-piperidinecarboxylic acid ethyl ester;ethyl 4-oxo-1-(phenylmethyl)piperidine-3-carboxylate;N-BENZYL-3-CARBOETHOXY-4-PIPERIDONE;LABOTEST-BB LT00440756 | | CAS: | 41276-30-6 | | MF: | C15H19NO3 | | MW: | 261.32 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 41276-30-6.mol |  |
| | 1-Benzyl-3-ethoxycarbonyl-4-piperidone Chemical Properties |
| Boiling point | 379.7±42.0 °C(Predicted) | | density | 1.154±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 10.77±0.20(Predicted) |
| | 1-Benzyl-3-ethoxycarbonyl-4-piperidone Usage And Synthesis |
| Synthesis | To a suspension of NaH (5.38 g, 0.13 mol) in
benzene, a solution of Michael adduct 131 (25 g,
0.09 mol) in PhH was added drop-wise and
refluxed for 3 hours. The reaction mixture was
allowed to cool and quenched with saturated
NH4Cl solution, extracted with ethyl acetate, washed with water, brine, dried over
anhydrous Na2SO4, filtered and concentrated in vacuo. Column chromatographic
separation over silica gel (EtOAc- pet ether) afforded ketoester, as a pale yellow oil (18.15
g).
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| | 1-Benzyl-3-ethoxycarbonyl-4-piperidone Preparation Products And Raw materials |
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