萘法唑酮盐酸盐
| 中文名称 | 萘法唑酮盐酸盐 |
|---|---|
| 中文同义词 | 萘法唑酮盐酸盐;盐酸奈法唑酮;盐酸萘法唑酮;盐酸奈法唑酮 标准品;萘法唑酮盐酸盐 USP标准品 |
| 英文名称 | Nefazodone hydrochloride |
| 英文同义词 | NEFAZODONE-D5 HCL;3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride;Nefazodone HCl;Nefazodone hydrochloride;NEFAZODONE;BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;Nefazodone Hydrochloride (200 mg) |
| CAS号 | 82752-99-6 |
| 分子式 | C25H33Cl2N5O2 |
| 分子量 | 506.47 |
| EINECS号 | |
| 相关类别 | 医药原料药;哌嗪;SERZONE;Active Pharmaceutical Ingredients;Serotonin receptor;API;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 82752-99-6.mol |
| 结构式 |  |
萘法唑酮盐酸盐 性质
| 熔点 | 186-188°C |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMSO: 11 mg/mL at 60 °C |
| 形态 | 固体 |
| 颜色 | 白色 |
| 最大波长(λmax) | 248nm(MeOH)(lit.) |
| Merck | 14,6438 |
| CAS 数据库 | 82752-99-6(CAS DataBase Reference) |
Nefazodone hydrochloride (BMY-13754) 是一种强效和选择性的 5HT2A (Ki=5.8 nM) 拮抗剂，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用 (IC50 分别为 290 和 300 nM)。Nefazodone hydrochloride 是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性。
|
5-HT 2A Receptor 5.8 nM (Ki) |
α1-adrenergic receptor
|
Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| 危险品运输编号 | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS号 | XZ5483009 |
| 海关编码 | 2933595960 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | N1030 | 奈法唑酮盐酸盐 Nefazodone Hydrochloride | 82752-99-6 | 200mg | 365元 |
| 2024/04/30 | HY-B1396 | Nefazodone hydrochloride | 5 mg | 437元 |