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| | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Basic information |
| Product Name: | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol | | Synonyms: | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol;3,3,-(2,4-diaminopteridine-6,7-diyl)diphenol;TG100-115;TG100115;TG100 115;6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine;3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol TG100-115;TG100-115, >=98%;TG100115; TG100 115;CS-427 | | CAS: | 677297-51-7 | | MF: | C18H14N6O2 | | MW: | 346.34 | | EINECS: | | | Product Categories: | Inhibitors;Akt;mTOR;PI3K;APIs | | Mol File: | 677297-51-7.mol |  |
| | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Chemical Properties |
| Boiling point | 699.6±65.0 °C(Predicted) | | density | 1.516±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in EtOH; ≥3.46 mg/mL in DMSO | | form | Yellow powder solid. | | pka | 8.54±0.10(Predicted) |
| | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Usage And Synthesis |
| Uses | TG100-115 is a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. It can provide potent cardioprotection, reduce infarct development, and preserve myocardial function. | | Definition | ChEBI: 3-[2,4-diamino-7-(3-hydroxyphenyl)-6-pteridinyl]phenol is a member of pteridines. | | Biological Activity | tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2]. | | target | PI3K-γ | | references | [1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.
[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65. |
| | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Preparation Products And Raw materials |
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