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| 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Basic information |
Product Name: | 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE | Synonyms: | 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;BUTTPARK 96\12-100;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;6-(4-tert-butylphenoxy)-3-pyridinamine;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103 | CAS: | 218457-67-1 | MF: | C15H18N2O | MW: | 242.32 | EINECS: | | Product Categories: | | Mol File: | 218457-67-1.mol | |
| 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties |
Melting point | 89-90 | storage temp. | 2-8°C | solubility | Soluble in DMSO (>30 mg/ml) | form | solid | color | Off-white to pale orange | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | CAS DataBase Reference | 218457-67-1(CAS DataBase Reference) |
Hazard Codes | Xi | Hazard Note | Irritant | HS Code | 2933399990 |
| 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Usage And Synthesis |
Description | CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors. | References | Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292 |
| 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Preparation Products And Raw materials |
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