| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:NDT 9513727
CAS:439571-48-9
Package:100Mg,10Mg,50Mg
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:NDT 9513727
CAS:439571-48-9
Purity:98% by HPLC Remarks:NDT 9513727 is a C5a receptor (C5aR) antagonist with IC50 value of 11.6 nM. NDT 9513727 can inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque. In the future, NDT 9513727 may be used for
|
|
| | NDT 9513727 Basic information |
| Product Name: | NDT 9513727 | | Synonyms: | NDT 9513727;N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine;1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl- | | CAS: | 439571-48-9 | | MF: | C36H35N3O4 | | MW: | 573.68 | | EINECS: | | | Product Categories: | Agonist, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 439571-48-9.mol |  |
| | NDT 9513727 Chemical Properties |
| Boiling point | 723.1±62.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mM; Ethanol: 100 mM | | form | A solid | | pka | 6.69±0.50(Predicted) |
| | NDT 9513727 Usage And Synthesis |
| Description | NDT 9513727 is a competitive antagonist of the C5a receptor (C5aR; IC50 = 11.6 nM for human recombinant receptors) that has inverse agonist activity in a GTPγ[35S] assay. It is selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 μM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively). NDT 9513727 inhibits degranulation in U937 cells stimulated with C5a (IC50 = 7.1 nM). It also prevents neutropenia induced by human recombinant C5a in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques when administered at doses of 5 and 25 mg/kg. | | Uses | NDT 9513727 is a selective, and potent inverse agonist of the human C5aR. NDT 9513727 has been shown to effectively inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo. These results suggest that NDT 9513727 is a promising candidate for the treatment of human inflammatory diseases. | | storage | Store at +4°C |
| | NDT 9513727 Preparation Products And Raw materials |
|