CS-2394
| 中文名称 | CS-2394 |
|---|---|
| 中文同义词 | 2-((3-(2-甲氧基苯基)-4-氧代-3,4,6,7-四氢噻吩并[3,2-D]嘧啶-2-基)硫代)-N-(6-甲基苯并[D]噻唑-2-基)乙酰胺;化合物IWP 4 |
| 英文名称 | IWP 4 |
| 英文同义词 | IWP 4;Wnt Inhibitor IWP-4;2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide;IWP4;IWP 4;CS-2394;Inhibitor of Wnt Production-4;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]- |
| CAS号 | 686772-17-8 |
| 分子式 | C23H20N4O3S3 |
| 分子量 | 496.62 |
| EINECS号 | |
| 相关类别 | 抑制剂 |
| Mol文件 | 686772-17-8.mol |
| 结构式 |  |
CS-2394 性质
| 密度 | 1.51±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 不溶于水；不溶于乙醇；不溶于DMSO |
| 酸度系数(pKa) | 9.01±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至浅棕色 |
IC50: 25 nM (Wnt)
IWP-4 is a small molecule Wnt inhibitor with an IC 50 of 25 nM. IWP-4 induces the expression of cardiac markers, including cardiac troponin I (CTNI) and cardiac myosin heavy chain bright cells (MYH hi + ). IWP-4 also results in the appearance of beating foci (0.44±0.10 SEM beats per second), which is absent in all cultures not receiving IWP-4. Further, flow cytometric analysis shows that there are significantly more MYH lo + cells in IWP-4 treated cultures (P<0.0002) compare with untreated cultures at day 16, being 17.0±1.3 SD% and 5.4±1.4 SD%, respectively. Quantification of NKX2-5 protein expression shows that 63% (481/817) of IWP-4 treated cells display nuclear NKX2-5 expression. Mesenchymal precursor cells (MPCs) treated with IWP-4 show no significant changes in the expression of AXIN2 , CTNNB1 and GSK3B as compare to osteogenic medium alone on day 7, but MPCs treated with IWP-4 express elevates levels of DKK1 and GSK3β on day 21. IWP-4 also causes a significant down regulation of SPARC and COL1A1 .
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12879 | IWP-4 | 1 mg | 438元 | |
| 2024/04/30 | HY-12879 | CS-2394 IWP-4 | 686772-17-8 | 5mg | 1500元 |