RAD51 INHIBITOR B02
| 中文名称 | RAD51 INHIBITOR B02 |
|---|---|
| 中文同义词 | RAD51抑制剂(RAD51 INHIBITOR B02);化合物B02;RAD51 INHIBITOR B02游离态;RAD51抑制剂B02;(E)-3-苄基-2-(2-(吡啶-3-基)乙烯基)喹唑啉-4(3H)-酮;B02,RAD51重组酶抑制剂 |
| 英文名称 | 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone |
| 英文同义词 | 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone;RAD51 Inhibitor B02;B02;BO2;RAD51 Inhibitor B02 >=98% (HPLC);4(3H)-Quinazolinone, 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-;(E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one;CS-2461 |
| CAS号 | 1290541-46-6 |
| 分子式 | C22H17N3O |
| 分子量 | 339.39 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;标准品 |
| Mol文件 | 1290541-46-6.mol |
| 结构式 |  |
RAD51 INHIBITOR B02 性质
| 熔点 | 174-175o C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 粉末 |
| 颜色 | 淡黄色至深黄色 |
| 稳定性 | 吸湿性 |
IC50: 27.4 μM (hRAD51)
RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC 50 =27.4 μM), but not its E. coli homologue RecA (IC 50 >250 μM). The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231.
B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo . B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101462 | RAD51 Inhibitor B02 | 1 mg | 308元 | |
| 2024/04/30 | HY-101462 | RAD51 INHIBITOR B02 RAD51 Inhibitor B02 | 1290541-46-6 | 5mg | 770元 |