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| | 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Basic information |
| | 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Chemical Properties |
| Melting point | 271℃ | | Boiling point | 600.3±55.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | pka | 4.28±0.70(Predicted) | | color | White to Off-White | | LogP | 7.418 (est) |
| Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2918300000 |
| | 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Usage And Synthesis |
| Description | 3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner. 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer. | | Uses | 3-Acetyl-11-keto-β-boswellic Acid (AKBA), be used in the place of the non-steroidal anti-inflammatory drug. AKBA, also inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway. It can be used as an anticancer agent. | | Definition | ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid. | | in vitro | akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1]. | | in vivo | pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1]. | | IC 50 | 1.5 μm | | references | [1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180. |
| | 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials |
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