托普雄酮
| 中文名称 | 托普雄酮 |
|---|---|
| 中文同义词 | 托普雄酮;化合物 T13187 |
| 英文名称 | topterone |
| 英文同义词 | topterone;17β-Hydroxy-17-propylandrost-4-en-3-one;Win-17665;Androst-4-en-3-one, 17-hydroxy-17-propyl-, (17β)- |
| CAS号 | 60607-35-4 |
| 分子式 | C22H34O2 |
| 分子量 | 330.509 |
| EINECS号 | 2623214 |
| 相关类别 | |
| Mol文件 | 60607-35-4.mol |
| 结构式 |  |
托普雄酮 性质
| 熔点 | 114.6-116.0 °C(Solv: benzene (71-43-2); hexane (110-54-3)) |
|---|---|
| 沸点 | 459.8±45.0 °C(Predicted) |
| 密度 | 1.08±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 15.13±0.60(Predicted) |
Androgen
Topterone, is administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrates that Topterone is both antiandrogenic and progestational. Topical application fails to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response is seen at 32 mg/kg/day. No other endocrine activities are detected. Topterone inhibits stimulation of flank organ development of castrated immature male hamsters by both testosterone and dihydrotestosterone, whereas Progesterone inhibits the stimulation by only testosterone. Topical application of Topterone, has been shown to cause a regression in the development of the flank organ.