长春考酯
| 中文名称 | 长春考酯 |
|---|---|
| 中文同义词 | 长春考酯;化合物 T13959 |
| 英文名称 | vinconate |
| 英文同义词 | vinconate;Vintenate;Chanodesethylapovinc?amine;Vincote;1H-Indolo[3,2,1-de][1,5]naphthyridine-6-carboxylic acid, 3-ethyl-2,3,3a,4-tetrahydro-, methyl ester |
| CAS号 | 70704-03-9 |
| 分子式 | C18H20N2O2 |
| 分子量 | 296.368 |
| EINECS号 | 2747897 |
| 相关类别 | |
| Mol文件 | 70704-03-9.mol |
| 结构式 |  |
长春考酯 性质
| 熔点 | 120-121° |
|---|---|
| 沸点 | 363.6±42.0 °C(Predicted) |
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.00±0.40(Predicted) |
muscariic acetylcholine receptor
Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [ 3 H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [ 3 H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [ 3 H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [ 3 H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats.