二甲他林
| 中文名称 | 二甲他林 |
|---|---|
| 中文同义词 | 二甲他林;化合物 T15132 |
| 英文名称 | Dimetacrine |
| 英文同义词 | Dimetacrine;dimethacrine;9,10-Dihydro-9,9-dimethyl-10-(3-dimethylaminopropyl)acridine;9,9-Dimethyl-10-[3-(dimethylamino)propyl]acridan;3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine;3-(9,9-dimethylacridin-10-yl)-N,N-dimethylpropan-1-amine;3-(9,9-dimethylacridin-10-yl)propyl-dimethyl-amine;10(9H)-AcridinepropanaMine,N,N,9,9-tetraMethyl- |
| CAS号 | 4757-55-5 |
| 分子式 | C20H26N2 |
| 分子量 | 294.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 4757-55-5.mol |
| 结构式 |  |
二甲他林 性质
| 沸点 | bp1 200° |
|---|---|
| 密度 | 0.9927 (rough estimate) |
| 折射率 | 1.5640 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.49±0.28(Predicted) |
Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. Dimetacrine in the highest concentration, 10 μM, decreases the contractile force to 36.5±9.1%. Dimetacrine, 0.3 μM, causes no statistically significant decline in contractile force from the controls. Tachycardia is observed after the administration of Dimetacrine, 1 to 3 mg/kg i.v., and the maximum response is obtained in dose of 3 mg/kg i.v.. The administration of Dimetacrine, 30 mg/kg i.v., causes an abrupt fall in blood pressure with tachycardia or bradycardia followed by cardiac arrest. Respiratory rate increases 40 min after the onset of infusion of Dimetacrine. Arterial blood pressure falls 50 min after the onset of infusion of Dimetacrine.