二嗪农
| 中文名称 | 二嗪农 |
|---|---|
| 中文同义词 | 75%二氰蒽醌可湿性粉剂;二氰蒽醌 (二噻农);二嗪农/二氰蒽醌;二噻农(标准品);二氰蒽醌溶液,100PPM;3-二氰基-1;4-二硫代蒽醌;5,10-二氢-5,10-二氧萘基[2,3-B]-1,4-二硫杂环-2,3-二腈 |
| 英文名称 | DITHIANON |
| 英文同义词 | 1,4-dithiaanthraquinone-2,3-dicarbonitrile;3-b)-p-dithiin-2,3-dicarbonitrile,5,10-dihydro-5,10-dioxo-naphtho(;3-b]-1,4-dithiin-2,3-dicarbonitrile,5,10-dihydro-5,10-dioxo-Naphtho[2;5,10-dihydroxy-5,10-dioxonaphtho-(2,3,b)-p-dithiin-2,3-dicarbonitrile;delan(fungicide);dithianone;it931;dithianon (bsi,iso,jmaf) |
| CAS号 | 3347-22-6 |
| 分子式 | C14H4N2O2S2 |
| 分子量 | 296.32 |
| EINECS号 | 222-098-6 |
| 相关类别 | 有机原料;农药中间体;中间体;农残、兽药及化肥类;杀菌剂类;农药;Alpha sort;D;DAlphabetic;DIO - DIZPesticides;Fungicides;Pesticides&Metabolites;Quinones |
| Mol文件 | 3347-22-6.mol |
| 结构式 |  |
二嗪农 性质
| 熔点 | 225° |
|---|---|
| 沸点 | 402.1±45.0 °C(Predicted) |
| 密度 | d18 1.55 |
| 折射率 | 1.6360 (estimate) |
| 储存条件 | 0-6°C |
| 水溶解性 | 0.5mg/L(temperature not stated) |
| Merck | 13,3404 |
| BRN | 1325563 |
| LogP | 2.840 |
| CAS 数据库 | 3347-22-6(CAS DataBase Reference) |
| NIST化学物质信息 | Dithianone(3347-22-6) |
| EPA化学物质信息 | Dithianon (3347-22-6) |
Reactive oxygen species (ROS)
Colletotrichum sp.
;
Elsinoe ampelina
;
Plasmopara viticola
;
Phomopsis viticola
When exponentially aerobic growing cells of
S. cerevisiae
are submitted to acute Dithianon treatment they loss cell wall and membrane integrity, dying by necrosis, and this behavior is associated to a depletion of reduced proteic and non-proteic thiol groups. An important increase of cellular reactive oxygen species (ROS) associated to mitochondrial membrane potential modifications on Dithianon treated cells are also detected.
In filamentous fungus, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells showed that Dithianon inhibits respiration and fermentation affecting several thiol enzymes of the glycolytic pathway as hexokinase, phosphofructokinase, and glyceraldeyde-3-phosphate dehydrogenase.
Dithianon has in vitro cytotoxic effect and affect cell transforming activity of BLAB/c 3 T3 cells.
The activity of testosterone hydroxylase of liver microsomes derived from male mice is increased when they are treated with acute doses of Dithianon, while in females an inactivating effect is observed.
安全信息
| 危险品标志 | Xn;N,N,Xn |
|---|---|
| 危险类别码 | 22-50/53 |
| 安全说明 | 24-60-61 |
| 危险品运输编号 | UN 3077 |
| WGK Germany | 3 |
| RTECS号 | QL0700000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 29349990 |
| 毒害物质数据 | 3347-22-6(Hazardous Substances Data) |
| 毒性 | LD50 orally in rats, guinea pigs: 638, 110 mg/kg (Amadori, Heupt) |
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