盐酸恩诺沙星
| 中文名称 | 盐酸恩诺沙星 |
|---|---|
| 中文同义词 | 恩诺沙星单盐酸盐 |
| 英文名称 | ENROFLOXAIN HYDROCHLORIDE |
| 英文同义词 | ENROFLOXAIN HYDROCHLORIDE;3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI) |
| CAS号 | 93106-59-3 |
| 分子式 | C19H23ClFN3O3 |
| 分子量 | 395.8556232 |
| EINECS号 | 274-614-4 |
| 相关类别 | 兽药原料;医药原料;Pharmacutical raw materials |
| Mol文件 | 93106-59-3.mol |
| 结构式 |  |
盐酸恩诺沙星 性质
| 储存条件 | Store at -20°C |
|---|---|
| 水溶解性 | Water : 7.14 mg/mL (Need ultrasonic) |
MIC90: 0.312 μg/mL ( Mycoplasma bovis )
Mycoplasma bovis is a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The antibiotic susceptibility profiles of the Hungarian strains are consistent within the tested group of fluoroquinolones. Three isolates (MYC44, MYC45 and MYC46) have high MIC values (≥10 μg/mL) to Enrofloxacin, while the rest of the strains are inhibited by Enrofloxacin with MICs ≤0.312 or 0.625 μg/mL.
Mice (n=80) undergo transient middle cerebral artery occlusion (MCAo) with reperfusion after 60 minutes. After MCAo, animals are randomly assigned to receive either a daily preventive medication (n=26, Enrofloxacin) starting at the day of MCAo or a therapeutic medication (n=25; Enrofloxacin) after diagnosis of lung infection. Standard treatment started immediately after the appearance of clinical signs (general health score>6) usually between day 4 and 6 after stroke. Both, preventive and standard antibiotic treatment using Enrofloxacin improve survival in a similar way compared with placebo treatment.