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| | Hycanthone Basic information |
| Product Name: | Hycanthone | | Synonyms: | 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE;ETRENOL;Etrenol(mesylate);Win 249-33;1-(2-diethylaminoethylamino)-4-methylol-thioxanthen-9-one;9H-Thioxanthen-9-one, 1-[[2-(diethylaMino)ethyl]aMino]-4-(hydroxyMethyl)-;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one | | CAS: | 3105-97-3 | | MF: | C20H24N2O2S | | MW: | 356.48 | | EINECS: | 221-463-7 | | Product Categories: | | | Mol File: | 3105-97-3.mol |  |
| | Hycanthone Chemical Properties |
| Melting point | 100.6-102.8° | | Boiling point | 570.5±50.0 °C(Predicted) | | density | 1.1269 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO : 30 mg/mL (84.16 mM) | | pka | pKa 3.40 (Uncertain) | | EPA Substance Registry System | Hycanthone (3105-97-3) |
| | Hycanthone Usage And Synthesis |
| Uses | Antischistosomal. | | Uses | Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone (L473700), which is used in the treatment of schistosomiasis. | | Definition | ChEBI: A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual
or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel. | | General Description | Odorless canary yellow to yellow-orange crystalline powder. Bitter taste. | | Air & Water Reactions | 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE may be sensitive to prolonged exposure to air and light. Highly soluble in water. | | Reactivity Profile | 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is very sensitive to acid. . | | Fire Hazard | Flash point data for 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE are not available; however, 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is probably combustible. | | Safety Profile | Poison by
subcutaneous, intravenous, and
intramuscular routes. Moderately toxic by
ingestion. Experimental teratogenic effects.
Human mutation data reported.
Questionable carcinogen with experimental
carcinogenic data. When heated to
decomposition it emits very toxic fumes of
NOx and SOx. |
| | Hycanthone Preparation Products And Raw materials |
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