- 1,3-Diaminopropan-2-ol
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- $8.00 / 1KG
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2024-01-22
- CAS:616-29-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 1,3-Diamino-2-propanol
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- $0.00 / 25KG
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2023-10-14
- CAS:616-29-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- 1,3-Diamino-2-propanol
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- $0.00 / 1KG
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2023-09-06
- CAS:616-29-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 1,3-Diamino-2-propanol Basic information |
| Product Name: | 1,3-Diamino-2-propanol | | Synonyms: | 1,3-diamino-2-propano;1,3-DIAMINO-2-HYDROXYPROPAN;1,3-DIAMINO-2-PROPANOL;2-HYDROXY-1,3-DIAMINOPROPANE;1,3-Diamino-2-hydroxypropane, tech;2-hydroxy-1,3-propylenediamine;1,3-Diamino-2-propanol,1,3-Diamino-2-hydroxypropane;2-Hydroxy-1,3-propanediamine | | CAS: | 616-29-5 | | MF: | C3H10N2O | | MW: | 90.12 | | EINECS: | 210-474-2 | | Product Categories: | Aliphatics;Amines | | Mol File: | 616-29-5.mol |  |
| | 1,3-Diamino-2-propanol Chemical Properties |
| Melting point | 40-44 °C(lit.) | | Boiling point | 235°C | | density | 1.0352 (rough estimate) | | refractive index | 1.4610 (estimate) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | water: soluble1g/10 mL | | form | Low Melting Solid | | pka | 9.69, 7.93(at 20℃) | | color | White to yellow | | Water Solubility | Very soluble in water. | | BRN | 741859 | | InChI | InChI=1S/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2 | | InChIKey | UYBWIEGTWASWSR-UHFFFAOYSA-N | | SMILES | C(N)C(O)CN | | CAS DataBase Reference | 616-29-5(CAS DataBase Reference) | | EPA Substance Registry System | 2-Propanol, 1,3-diamino- (616-29-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | 3259 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221990 |
| | 1,3-Diamino-2-propanol Usage And Synthesis |
| Description | 1,3-Diamino-2-propanol (DAP), also known as 2-hydroxy-1,3-diaminopropane, is a white to yellowish low melting solid. Keep in a cool, well-ventilated place. Avoid prolonged storage periods. Store under inert gas, in a tightly sealed container and at ambient temperatures. 1,3-Diamino-2-propanol is incompatible with acids and strong oxidizing agents and should not be stored or handled in their vicinity. | | Chemical Properties | white to yellowish low melting solid | | Uses | - 1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.
- It is a precursor to synthesize the fluorogenic dsDNA binder, N1,N3-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).
- It can also be used as a branching unit in the synthesis of peptide dendrimers.
| | Application | 1,3-diamino-2-propanol (DAPL), a close analog of 1,3-diaminopropane, is an indirect inhibitor of ornithine decarboxylase (ODC). It is administered orally and inhibits ODC activity in the livers of partially hepatectomized rats[1]. It contains amine and hydroxyl groups. Therefore, it can be crosslinked with the carboxyl group via covalent and hydrogen bonds and has been investigated as a diamine monomer in the aqueous phase to fabricate the high-performance RO membrane[2]. | | Preparation | 1,3-Diamino-2-propanol is synthesized by reacting Epichlorohydrin with ammonia in alkaline
environment by adding sodium hydroxide. Afterwards, the product
undergoes a series of purification steps.
 | | Hazard | 1,3-Diamino-2-propanoli is a hazardous chemical.
H302 (66.17%): Harmful if swallowed [Warning Acute toxicity, oral]. H314 (66.92%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]. H315 (33.08%): Causes skin irritation [Warning Skin corrosion/irritation]. H317 (66.17%): May cause an allergic skin reaction [Warning Sensitization, Skin]. H318 (66.17%): Causes serious eye damage [Danger Serious eye damage/eye irritation]. H319 (33.08%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]. H335 (34.59%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation. | | Purification Methods | Dissolve it in an equal amount of water, shake it with charcoal and distil it at 68o/0.1mm. The distillate solidifies. It is too viscous to be distilled through a packed column. [Beilstein 4 IV 1694.] | | References | [1] Raunio H, et al. The inhibition of induction of microsomal monooxygenase activity by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase. Biochemical and Biophysical Research Communications, 1979; 9: 285–290.
[2] Su T, et al. A novel polyamide thin-film nanocomposite reverse osmosis membrane constructed by a 3D multi-layer graphene oxide assembled with 1,3-diamino-2-propanol. Journal of Membrane Science, 2023; 681: 121773.
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| | 1,3-Diamino-2-propanol Preparation Products And Raw materials |
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