1,6-双(环己基脒基羰基氨基)己烷
| 中文名称 | 1,6-双(环己基脒基羰基氨基)己烷 |
|---|---|
| 中文同义词 | 1,6-双(环己基脒基羰基氨基)己烷;RHC-80267,二酰基甘油脂肪酶抑制剂 |
| 英文名称 | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE |
| 英文同义词 | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;RHC-80267;U-57908;N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine);1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane;1,6-bis(cyclohexyloximinocarbonyl)hexane;1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908;Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime |
| CAS号 | 83654-05-1 |
| 分子式 | C20H34N4O4 |
| 分子量 | 394.52 |
| EINECS号 | |
| 相关类别 | Lipid signaling |
| Mol文件 | 83654-05-1.mol |
| 结构式 |  |
1,6-双(环己基脒基羰基氨基)己烷 性质
| 熔点 | 118-121℃ |
|---|---|
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| RTECS号 | GW1485000 |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 二甲基亚砜：9 mg/毫升 |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.81±0.46(Predicted) |
| 颜色 | 白色 |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月 |
1,6-双(环己基脒基羰基氨基)己烷可抑制多种细胞类型和组织中的DAG 脂肪酶活性，包括犬血小板、牛肾上腺嗜铬细胞、人肾上腺肾小球细胞、大鼠甲状腺叶和胰腺小叶。 犬血小板中的 IC50 为 4 μM。
RHC 80267 (U-57908) 是一种有效的、具有选择性的 diacylglycerol lipase (DAGL, DAG lipase) 的抑制剂，其对 cholinesterase 活性的IC50值为4 μM。RHC 80267 可抑制 cyclooxygenase (COX) 的活性，phospholipase C (PLC) 的活性和 phosphatidylcholine (PC) 的水解作用。| Target | Value |
|
cholinesterase
(Cell-free assay) | 4 μM |
The potentiation by RHC 80267 of the relaxation to acetylcholine could be caused by the inhibition of cholinesterase: (1) RHC 80267 does not affect the responses to carbachol, the carbamyl derivative of acetylcholine which only differs from acetylcholine by its resistance to hydrolysis by cholinesterase, and (2) the effect of RHC 80267 is mimicked by the inhibitor of cholinesterase neostigmine, RHC 80267 showing no additional effect in the presence of a maximally effective concentration of neostigmine. The determination of the effect of RHC 80267 on the cholinesterase activity of brain homogenate confirmed that RHC 80267 inhibits this enzyme in the same range of concentrations increasing the relaxation to acetylcholine, namely at 1-10 μM.
RHC 80267 (40 μM) enhances contractions induced by U46619 (a thromboxane A2 analog) in human and rat pulmonary arteries (hPAs and rPAs, respectively) and by angiotensin II (ANG II) in rPAs in an endothelium-dependent manner.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
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英文
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