- Pheniramine maleate
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- $0.00 / 25KG
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2023-09-08
- CAS:132-20-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- Pheniramine maleate
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- $2150.00 / 1KG
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2023-06-15
- CAS:132-20-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1-20mt
- Pheniramine maleate
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- $1.00 / 1kg
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2023-03-10
- CAS:132-20-7
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 20tons
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| | Pheniramine maleate Basic information |
| | Pheniramine maleate Chemical Properties |
| Melting point | 104-108°C | | Boiling point | 489.25°C (rough estimate) | | density | 1.2233 (rough estimate) | | refractive index | 1.6800 (estimate) | | storage temp. | 2-8°C | | solubility | Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. | | color | White | | Water Solubility | >=1 g/100 mL at 24 ºC | | λmax | 262nm(lit.) | | Merck | 14,7235 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 132-20-7(CAS DataBase Reference) | | EPA Substance Registry System | Pheniramine maleate (132-20-7) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | UT0175000 | | HS Code | 2933399090 |
| | Pheniramine maleate Usage And Synthesis |
| Chemical Properties | white powder | | Originator | Trimeton Maleate, Schering ,US,1948 | | Uses | Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria. | | Uses | Used medicinally as an antihistaminic (merck). | | Uses | A H1 histamine receptor antagonist. | | Uses | Antihistaminic;H1 antagonist | | Definition | ChEBI: Pheniramine maleate is an organic molecular entity. | | Manufacturing Process | According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid. | | Therapeutic Function | Antihistaminic | | General Description | White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic. | | General Description | Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts. | | Air & Water Reactions | Water soluble. | | Reactivity Profile | Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents. | | Fire Hazard | Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible. | | Biochem/physiol Actions | Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions. |
| | Pheniramine maleate Preparation Products And Raw materials |
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