| Company Name: |
Aikon International Limited
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| Tel: |
025-66113011 13155353615 |
| Email: |
qzhang@aikonchem.com |
| Products Intro: |
Product Name:proquazone
CAS:22760-18-5
Purity:95+% Package:1g;5g;10g
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| Company Name: |
Shanghai Kaiwei Chemical Technology Co., Ltd.
|
| Tel: |
021-58461859 15821823057 |
| Email: |
service@aiviche.com |
| Products Intro: |
Product Name:7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
CAS:22760-18-5
Purity:95% Package:1g;1kg
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| | proquazone Basic information |
| Product Name: | proquazone | | Synonyms: | 43-715;Biarison;Biarsan;SaH-43-715;Sandoz-43-715;7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone;proquazone;2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl- | | CAS: | 22760-18-5 | | MF: | C18H18N2O | | MW: | 278.35 | | EINECS: | 245-203-7 | | Product Categories: | | | Mol File: | 22760-18-5.mol |  |
| | proquazone Chemical Properties |
| Melting point | 137-138° | | Boiling point | 436.12°C (rough estimate) | | density | 1.1707 (rough estimate) | | refractive index | 1.5700 (estimate) | | pka | 0.74±0.20(Predicted) |
| | proquazone Usage And Synthesis |
| Uses | Anti-inflammatory. | | Uses | Proquazone is a non-steroidal anti-inflammatory drug. | | Definition | ChEBI: Proquazone is a member of pyrimidines. | | Brand name | Arthrex (Novartis), Biarison (Swiss-Pharma,
Egypt; Biochemie, Austria; ICN Alkaloida,
Hungary; Sandoz, Finland, Turkey). | | Clinical Use | Proquazone has been used successfully to
treat rheumatoid polyarthritis. At 900 mg/d it
is comparable in effect to 150 mg/d of indomethacin. Gastrointestinal disturbances are
the principal adverse effects observed with its
use. | | Synthesis | Synthesis: proquazone is prepared by the
alkylation of 2-amino-4-methylbenzophenone
with 2-iodopropane in the presence of
sodium carbonate to give 4-methyl-2-[(1-
methylethyl)amino]benzophenone, which is
condensed with urethane in the presence of
zinc chloride at 190 ?C.
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| | proquazone Preparation Products And Raw materials |
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