R,R-THC is a estrogen receptor-β selective antagonist. R,R-THC also inhibits DHEA and DHEA metabolite transcriptional activity in ERβ-transfected cells. R,R-THC has also been shown to have neuroprotective effects against glutamate-induced death in primary
中文名称
(R,R)-THC
中文别名
顺式-5,11-二乙基-5,6,11,12-四氢-2,8-屈二醇
英文名称
(R,R)-THC
英文别名
2,8-Chrysenediol,5,11-diethyl-5,6,11,12-tetrahydro-, (5R,11R)-rel-;(5R,11R)-5,11-DIETHYL-5,6,11,12-TETRAHYDRO-2,8-CHRYSENEDIOL;(R,R)-THC;cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol;(R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Cas No.
138090-06-9
分子式
C22H24O2
分子量
320.42
生物活性
(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6.
性状
Solid
IC50 & Target[1][2]
ERα
9.0 nM (Ki)
ERβ
3.6 nM (Ki)
运输条件
Room temperature or refrigerated transportation.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
[1]. Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804. [Information]
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