1-Methyl-1-nitrosourea

Flammable solids, Category 2

Acute toxicity - Category 3, Oral

Carcinogenicity, Category 1B

Reproductive toxicity, Category 1B

H228 Flammable solid

H301 Toxic if swalloed

H350 May cause cancer

H360 May damage fertility or the unborn child

P201 Obtain special instructions before use.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P203 Obtain, read and follow all safety instructions before use.

P370+P378 In case of fire: Use ... to extinguish.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P318 IF exposed or concerned, get medical advice.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Rinse with pure water for at least 15 minutes. Consult a doctor.

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

SYMPTOMS: Exposure to this compound may cause nausea, vomiting, epigastric pain, diarrhea and leukopenia. It may also cause skin rashes. Eye contact may cause damage to the retina, degeneration of pigment epithelium and destruction of the rods and outer nuclear layer leading to thinning of the whole retina and migration of pigment. Retinal atrophy and cataracts have also been reported. It may cause acetonuria. ACUTE/CHRONIC HAZARDS: This compound is toxic on skin contact or ingestion. It causes skin irritation. When heated to decomposition it emits toxic fumes of NOx. Decomposition products may be explosive. (NTP, 1992)

For immediate first aid: Ensure that adequate decontamination has been carried out. If victim is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. Nitrates, nitrites, and related compounds

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

no data available

Sensitive to humidity and light when pure. Insoluble in water. Slowly decomposes in water. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas.

Decomposes to diazomethane in alkaline soln; stability in aq soln is ph-dependent (at 20 deg c)

N-NITROSO-N-METHYLUREA is incompatible with strong acids and bases. Also incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Can detonate with (potassium hydroxide + methylene chloride) (NTP, 1992).

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Melting point: 124 deg c (decomp)

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The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated N-nitroso-N-methylurea for carcinogenicity. According to their analysis, the weight-of-evidence for N-nitroso-N-methylurea is group B2, which is based on sufficient evidence in animals. No data are available for humans. As a group B2 chemical, N-nitroso-N-methylurea is considered probably carcinogenic to humans.

No information is available on the reproductive or developmental effects of N-nitroso-n-methylurea in humans. Animal studies have reported tumors of the nervous system and kidneys in the offspring of rats treated with N-nitroso-n-methylurea during their pregnancy.

no data available

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An estimated BCF of 0.56 was calculated for N-nitroso-N-methylurea(SRC), using a measured log Kow of -0.03(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC). Based upon the hydrolysis of N-nitroso-N-methylurea in aqueous environments(4), bioconcentration is not expected to be an important fate process(SRC).

The Koc of N-nitroso-N-methylurea is estimated as approximately 23(SRC), using a measured log Kow of -0.03(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that N-nitroso-N-methylurea is expected to have very high mobility in soil(SRC). Based upon the hydrolysis of N-nitroso-N-methylurea in aqueous environments(4), adsorption to soil and leaching are not expected to be important processes(SRC).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN1325 (For reference only, please check.)

IMDG: UN1325 (For reference only, please check.)

IATA: UN1325 (For reference only, please check.)

ADR/RID: FLAMMABLE SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IMDG: FLAMMABLE SOLID, ORGANIC, N.O.S. (For reference only, please check.)

IATA: FLAMMABLE SOLID, ORGANIC, N.O.S. (For reference only, please check.)

ADR/RID: 4.1 (For reference only, please check.)

IMDG: 4.1 (For reference only, please check.)

IATA: 4.1 (For reference only, please check.)

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

ADR/RID: No

IMDG: No

IATA: No

no data available

no data available