Chemical Safety Data Sheet MSDS / SDS

4-Nitroaniline

Revision Date:2024-02-24Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 4-Nitroaniline
CBnumber: CB9852549
CAS: 100-01-6
EINECS Number: 202-810-1
Synonyms: 4-nitroaniline,P-NITROANILINE

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P405 Store locked up.

P330 Rinse mouth.

P320 Specific treatment is urgent (see … on this label).

P311 Call a POISON CENTER or doctor/physician.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

Hazard statements

H412 Harmful to aquatic life with long lasting effects

H402 Harmful to aquatic life

H373 May cause damage to organs through prolonged or repeated exposure

H331 Toxic if inhaled

H330 Fatal if inhaled

H311 Toxic in contact with skin

H310 Fatal in contact with skin

H301 Toxic if swalloed

H300 Fatal if swallowed

SECTION 3: Composition/information on ingredients

Substance

Product name: 4-Nitroaniline
Synonyms: 4-nitroaniline,P-NITROANILINE
CAS: 100-01-6
EC number: 202-810-1
MF: C6H6N2O2
MW: 138.12

SECTION 4: First aid measures

Description of first aid measures

General advice

First aider needs to protect himself. Show this material safety data sheet to the doctor in

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	3	Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	2	Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Moisture sensitive.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Body Protection

protective clothing

Respiratory protection

Recommended Filter type: Filter A-(P2)

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

Exposure limits

NIOSH REL: TWA 3; IDLH 300; OSHA PEL: TWA 6; ACGIH TLV: TWA 3 (adopted).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearanceyellow crystalline
OdourAmmonia odor
Odour ThresholdNo data available
pH7,0
Melting point/freezing pointMelting point/range: 146 - 149 °C - lit.
Initial boiling point and boiling range260 °C at 133 hPa - lit.
Flash point213,0 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsNo data available
Vapour pressure 0,005 hPa at 25,0 °C
Vapour density 4.77 (vs air)
Relative density1,44 g/cm3
Water solubilityslightly soluble
Partition coefficient: n-octanol/waterlog Pow: 1,39log Pow: 5
Autoignition temperature180,0 °C
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant1.15 x 10^-9 atm?m³/mol at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

Forms explosive mixtures with air on intense heating.

A range from approx. 15 Kelvin below the flash point is to be rated as critical.

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Risk of ignition or formation of inflammable gases or vapours with: Organic Substances

magnesium Nitric acid

Exothermic reaction with:

sulfuric acid

Risk of explosion with:

Sodium hydroxide organic nitro compounds Ether

Violent reactions possible with:

strong reducing agents Bases

Acid chlorides Acid anhydrides

Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!

Conditions to avoid

Strong heating.

Incompatible materials

rubber, various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 750,0 mg/kg
LD50 Dermal - Guinea pig - > 500,0 mg/kg

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

May cause damage to organs through prolonged or repeated exposure.

Aspiration hazard

No data available

Toxicity

Acute LD₅₀ for wild birds 75 mg/kg, guinea pigs 450 mg/kg, mice 810 mg/kg, quail 1,000 mg/kg, rats 750 mg/kg (quoted, RTECS, 1985).

SECTION 12: Ecological information

Toxicity

Toxicity to fish

LC50 - Pimephales promelas (fathead minnow) - 85,7 - 142 mg/l - 96,0 h

LC50 - Leuciscus idus (Golden orfe) - 35 mg/l - 48,0 h LC50 - Danio rerio (zebra fish) - 87,6 mg/l - 96,0 h

Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 17,00 mg/l - 48 h

Toxicity to algae

EC50 - No information available. - 68,00 mg/l - 24 h

Persistence and degradability

No data available

Bioaccumulative potential

Bioaccumulation Danio rerio (zebra fish) - 96 h

- 0,028 mg/l(4-Nitroaniline)

Bioconcentration factor (BCF): 4,4

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Incompatibilities

A combustible liquid. A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion.

Waste Disposal

Incineration (982℃, 2.0 seconds minimum) with scrubbing for nitrogen oxides abatement. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

SECTION 14: Transport information

UN number

ADR/RID: 1661 IMDG: 1661 IATA: 1661

UN proper shipping name

ADR/RID: NITROANILINES

IMDG: NITROANILINES (o-, m-, p-)

IATA: Nitroanilines

Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

EC Inventory:Listed.

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is indicated.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.See ICSCs 0306 and 0307.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.