ChemicalBook CAS DataBase List (+/-)1-(1-Naphthyl)ethylamine

(+/-)1-(1-Naphthyl)ethylamine synthesis

5synthesis methods

Product Name:(+/-)1-(1-Naphthyl)ethylamine
CAS Number:42882-31-5
Molecular formula:C12H13N
Molecular Weight:171.24

Phosphinic amide, N-[1-(1-naphthalenyl)ethyl]-P,P-diphenyl-

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Yield:42882-31-5 80%

Reaction Conditions:

with hydrogenchloride in ethanol at 20; for 2 h;

Steps:

17 EXAMPLE 17; Synthesis of 1-Naphthylethylamine

Gaseous hydrogen chloride was bubbled through a stirred solution of N-diphenylphosphinyl-1-naphthylethylamine in ethyl alcohol for 2 hours at room temperature. The reaction mixture was concentrated, made basic by the addition of an aqueous solution of sodium hydroxide (2 M) and extracted with dichloromethane (3×10 ml). The organic layer was washed with brine (1×10 ml), dried over magnesium sulphate and concentrated to give the product as a yellow liquid in 80% yield.

References:

US6696608,2004,B1 Location in patent:Page column 28

941-98-0 Synthesis