3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride synthesis
- Product Name:3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
- CAS Number:762240-92-6
- Molecular formula:C6H7F3N4.ClH
- Molecular Weight:228.6
![N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide](/CAS/GIF/763105-70-0.gif)
763105-70-0
42 suppliers
$462.00/1g
762240-92-6
518 suppliers
$25.00/1g
Yield:762240-92-6 92.6%
Reaction Conditions:
with hydrogenchloride in ethanol;water at 50 - 54; for 3.5 h;Temperature;
Steps:
2-5
Take 52.54g (0.25mol) of the intermediate N-[(2Z)-piperazin-2-ylidene]trifluoroacethydrazine obtained above, add 600ml of ethanol, and stir until uniform.Drop 27.88g (0.28mol) of 36% hydrochloric acid, and heat to 50-54°C,Incubate the reaction for 3.5 hours to form a ring and form a salt. After the reaction is over,Slowly lower the temperature to 0-5 to charge the analytical crystal, filter by suction, and dry the wet product,Obtain the target product sitagliptin intermediate 3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4-triazole[4,3-a]pyrazine hydrochloride 52.92g, The yield is 92.6%, the purity is greater than or equal to 99.4%, and the content is greater than or equal to 98.7%
References:
CN112358484,2021,A Location in patent:Paragraph 0024; 0030; 0034-0035; 0039-0040; 0044-0045; 0049
![3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine](/CAS/GIF/486460-20-2.gif)
486460-20-2
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762240-92-6
518 suppliers
$25.00/1g
![3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine](/CAS/GIF/486460-21-3.gif)
486460-21-3
210 suppliers
$15.00/250mg
762240-92-6
518 suppliers
$25.00/1g