ChemicalBook CAS DataBase List 5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione

5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione synthesis

12synthesis methods

Product Name:5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione
CAS Number:144809-28-9
Molecular formula:C19H18N2O3S
Molecular Weight:354.42

110-89-4
3 suppliers
$15.96/100ML

2295-31-0 Synthesis

2295-31-0
514 suppliers
$6.00/5g

4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyaldehyde

114393-97-4
74 suppliers
$275.00/100mg

5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione

144809-28-9
165 suppliers
$120.09/10 mg

Yield: 99.5%

Reaction Conditions:

in ethanol

Steps:

R.4 Production of 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzilidene]-2,4-thiazolinedione
Reference Example 4 Production of 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzilidene]-2,4-thiazolinedione In 1.1 liter of ethanol was dissolved 94 g of 4-[2(5-ethyl-2-pyridyl) ethoxy]benzaldehyde (content 80.6%) obtained by substantially the same manner as b) of Example 1. To the solution were added 93.7 g of 2,4-thiazolidinedione and 19.7 g of piperidine, and the mixture was stirred for 5 hours under reflux. The reaction mixture was gradually cooled to room temperature. Resulting crystals were collected by filtration under reduced pressure, washed with 100 ml of ethanol and dried at 50° C. under reduced pressure to give 77.1 g of 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzilidene]-2,4-thiazolidinedione as pale yellow crystals (content 99.5%).

References:

Takeda Chemical Industries, Ltd. US5554758, 1996, A