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2,2-BIS-(HYDROXYMETHYL)-PROPANOIC ACID BENZYL ESTER synthesis

3synthesis methods
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Yield: 74.2%

Reaction Conditions:

Stage #1:2,2-bis(hydroxymethyl)propionic acid with potassium hydroxide in N,N-dimethyl-formamide at 100; for 1 h;
Stage #2:benzyl chloride in N,N-dimethyl-formamide at 100; for 12 h;

References:

Liu, Xinli;Cui, Dongmei;Hua, Xiufang [Macromolecules,2020,vol. 53,# 13,p. 5289 - 5296]

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