ChemicalBook CAS DataBase List 2-ACETAMIDO-5-AMINOPYRIDINE

2-ACETAMIDO-5-AMINOPYRIDINE synthesis

4synthesis methods

Product Name:2-ACETAMIDO-5-AMINOPYRIDINE
CAS Number:29958-14-3
Molecular formula:C7H9N3O
Molecular Weight:151.17

5093-64-1 Synthesis

5093-64-1
164 suppliers
$11.00/1g

29958-14-3
140 suppliers
$17.00/1g

Yield:29958-14-3 84%

Reaction Conditions:

with water;ammonium chloride;zinc in ethanol at 20; for 5 h;

Steps:

1 N - (5 - aminopyridine -2 - yl) acetamide (6 a) preparation of
The 5 a (1.0 g, 5.5 mmol) add 10 ml 95% ethanol, then adding zinc powder (3.6 g, 55.1 mmol) and ammonium chloride (3.0 g, 56.1 mmol), and dropwise 2 ml water, stir at room temperature 5 h, ethyl acetate extraction, anhydrous MgSO₄Drying, filtering, turns on lathe does, column chromatography purification forms offwhite solid 0.7 g, yield 84%.

References:

China Pharmaceutical University;Lai Yisheng;Zhu Bao;Guo Yi;Li Yuezhen;Zhang Yihua CN106946890, 2017, A Location in patent:Paragraph 0097; 0098; 0099

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4214-76-0 Synthesis