ChemicalBook CAS DataBase List 2-CHLORO-4-IODOTOLUENE

2-CHLORO-4-IODOTOLUENE synthesis

5synthesis methods

Product Name:2-CHLORO-4-IODOTOLUENE
CAS Number:83846-48-4
Molecular formula:C7H6ClI
Molecular Weight:252.48

95-49-8 Synthesis

95-49-8
328 suppliers
$10.00/5g

83846-48-4
121 suppliers
$13.00/25g

Yield: 67%

Reaction Conditions:

with dipotassium peroxodisulfate;choline chloride;iodine in acetonitrile at 65; for 3 h;

Steps:

General procedure for iodination of aromatic compounds:
General procedure: To a solution of aromatic compound (10 mmol) in acetonitrile (5 mL) in a 100 mL round-bottomed flask with a magnetic bar was added choline chloride(10 mmol), potassium peroxodisulfate (10 mmol) and iodine (15 mmol). The reaction mixture was stirred for the appropriate time at 65 °C. The progress of the reaction was monitored by TLC. The reaction mixture was poured into aqueous sodium thiosulfate solution (1 mol/L) in order to remove unreacted iodine and extracted with ethyl acetoacetate (10 mL, 3 times). Organic layer is dried over anhydrous sodium sulphate. Evaporation of the solvent under vacuum followed by column chromatography on silica gel gave the corresponding iodinated compounds (Scheme-I).

References:

Parthiban;Joel Karunakaran [Asian Journal of Chemistry,2018,vol. 30,# 7,p. 1659 - 1663]

95-49-8 Synthesis

95-49-8
328 suppliers
$10.00/5g

42048-11-3 Synthesis