ChemicalBook CAS DataBase List 2-N-PROPYLTHIOPHENE

2-N-PROPYLTHIOPHENE synthesis

9synthesis methods

Product Name:2-N-PROPYLTHIOPHENE
CAS Number:1551-27-5
Molecular formula:C7H10S
Molecular Weight:126.22

13679-75-9
147 suppliers
$10.00/5g

1551-27-5
97 suppliers
$17.00/1g

Yield:1551-27-5 92%

Reaction Conditions:

with triethylsilane;trifluoroacetic acid at 0 - 20;

Steps:

6.2 6.2
Preparation of 2-n-propylthiophene
6.2
Preparation of 2-n-propylthiophene
2-propionylthiophene (1.5g) was dissolved in trifluoroacetic acid (10 mL) at 0 °C, added with 4 eq of triethyl silane, and stirred at room temperature overnight.
Purification by column chromatography gave 2-n-propylthiophene.
Yield, 92%.
¹H NMR (CDCl₃, 400 MHz): δ 7.10 (d, J = 4.0 Hz, 1H), 6,91 (dd, J= 4.0, J = 5.0 Hz, 1H), 6,78 (d, J= 5.0 Hz, 1H), 2.79 (t, J= 7.4 Hz, 2H), 1.69(m, 2H), 0.90(t, J = 7.4 Hz, 3H). ESI-MS m/z: 127.0 [M+H]⁺.

References:

Shanghai Institute of Materia Medica, Chinese Academy of Sciences;LIU, Hong;ZHEN, Xuechu;SUN, Haifeng;ZHU, Liyuan;QIAN, Wangke;YU, Leiping;LI, Zeng;ZHOU, Shengbin;CAI, Wenxian;JIANG, Hualiang;CHEN, Kaixian EP2848617, 2015, A1 Location in patent:Paragraph 0093; 0094

FullText

109-64-8 Synthesis