3-Butenenitrile synthesis
- Product Name:3-Butenenitrile
- CAS Number:109-75-1
- Molecular formula:C4H5N
- Molecular Weight:67.09
Yield:109-75-1 91.3%
Reaction Conditions:
with tetrabutylammomium bromide in toluene at 60; for 6 h;
Steps:
1 Preparation of 3-cyanopropylene
To a 1000 ml flask was added 300 g of toluene,76.5 g (1.0 mol) of 3-chloropropene,1.0 g of tetrabutylammonium bromide,170 g of a 30% aqueous solution of sodium cyanide,The temperature was raised to 60 ° C for 6 hours.Reaction is completed,Cool to room temperature.Layered,The aqueous layer was extracted twice with toluene (80 g each toluene)Combine organic phase,50 grams of 2% ferrous sulphate,50 g of saturated aqueous sodium chloride solution,The organic layer was dried with 15 g of anhydrous sodium sulfate for 4 hours,filter,Recovery of toluene,Distillation distillation (45-55 ° C / 10 mm Hg)To obtain 61.8 g of a colorless transparent liquid.Purity 99.5% (GC), the yield of 91.3%.
References:
XINFA PHARMACEUTICAL CO LTD;QI, YUXIN;LI, XINFA;ZHANG, MINGFENG;JU, LIZHU CN104230880, 2016, B Location in patent:Paragraph 0049-0050
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