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ChemicalBook CAS DataBase List 3-(DIFLUOROMETHOXY)BENZONITRILE

3-(DIFLUOROMETHOXY)BENZONITRILE synthesis

6synthesis methods
-

Yield: 47%

Steps:

7 Preparation of 3-difluoromethoxybenzonitrile
EXAMPLE 7 Preparation of 3-difluoromethoxybenzonitrile Following the procedure of Example 6, except substituting 3-cyanophenol (Aldrich) for 4-cyanophenol, the title compound was prepared as a clear liquid (0.08 g, 47%). MS(CI/NH3) m/e 187 ›M+NH4!.

References:

SmithKline Beecham Corporation US5731477, 1998, A

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