ChemicalBook CAS DataBase List 4-Morpholinoaniline

4-Morpholinoaniline synthesis

13synthesis methods

Product Name:4-Morpholinoaniline
CAS Number:2524-67-6
Molecular formula:C10H14N2O
Molecular Weight:178.23

10389-51-2
189 suppliers
$15.00/5g

2524-67-6
304 suppliers
$8.00/1g

Yield:2524-67-6 99%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethanol at 20; for 3 h;

Steps:

5.1.62. 1-methyl-1H-pyrazol-4-amine (18a)
General procedure: To 17a (1 g, 7.8 mmol) in EtOH (20 mL) was added 10% Pd/C50 mg. The reaction mixture was stirred for 3 h under hydrogen at roomtemperature. The mixture was then filtered with Celite, and the filtratewas concentrated and dried under vacuum to yield 0.74 g (97%) of 18aas a white solid. MS (ESI) m/z 98 [M+H]+.

References:

Yu, Ru-Nan;Chen, Cheng-Juan;Shu, Lei;Yin, Yuan;Wang, Zhi-Jian;Zhang, Tian-Tai;Zhang, Da-Yong [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 8,p. 1646 - 1657]

FullText

70291-67-7 Synthesis