4-Nitrophthalhydrazide synthesis
- Product Name:4-Nitrophthalhydrazide
- CAS Number:3682-19-7
- Molecular formula:C8H5N3O4
- Molecular Weight:207.14
89-40-7
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3682-19-7
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$60.00/100mg
Yield:3682-19-7 80%
Reaction Conditions:
with hydrazine hydrate in ethanol for 5 h;Reflux;
Steps:
45.1 Step 1: 6-nitro-2,3-dihydrophthalazine-l,4-dione
To a solution of 5-nitroisoindoline-l,3-dione (50.0 g, 0.26 mol) in EtOH (500 mL) was added hydrazine hydrate (52.0 g, 1.04 mol) at rt. Then the reaction mixture was refluxed for 5h. After cooled to rt, the reaction mixture was poured into water (300 mL) and the solid was filtered and washed with water (50 mL*3). The filtered cake was dried to afford 6-nitro-2,3- dihydrophthalazine-l,4-dione (43.0 g, 80%) as a yellow solid. [M+H] MS Calc’d C8H5N3O4, 208.0; Found: 208.0.
References:
KINNATE BIOPHARMA INC. WO2021/11796, 2021, A1 Location in patent:Paragraph 00337
5466-84-2
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3682-19-7
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$60.00/100mg
610-27-5
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3682-19-7
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67081-02-1
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3682-19-7
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88-99-3
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$15.00/50 g
3682-19-7
68 suppliers
$60.00/100mg