ChemicalBook CAS DataBase List 5-Chloro-2-fluoronitrobenzene

5-Chloro-2-fluoronitrobenzene synthesis

7synthesis methods

Product Name:5-Chloro-2-fluoronitrobenzene
CAS Number:345-18-6
Molecular formula:C6H3ClFNO2
Molecular Weight:175.54

89-61-2 Synthesis

89-61-2
7 suppliers
$10.00/5g

345-18-6
196 suppliers
$7.00/5g

Yield:345-18-6 77.2%

Reaction Conditions:

with potassium fluoride;bis(tricyclohexylphosphine)nickel(II) dichloride;tetrabutyl ammonium fluoride in N,N-dimethyl-formamide at 150; for 8 h;Inert atmosphere;

Steps:

7 Synthesis of 5-chloro-2-fluoro-nitrobenzene
Weigh 0.52g (0.75mmol) of dichloro-di-dicyclohexylphosphine nickel into a 250mL three-necked flask, add 2.88g (15.0mmol) of 2,5-dichloro-nitrobenzene,And add 40mL deoxygenated DMF, start stirring under nitrogen protection,Dissolve the material.Then 1.74g (30mmol) of potassium fluoride and 0.24g (0.75mmol) of tetrabutylammonium fluoride were added. Start stirring,Heat to a slight boiling (150) under the protection of nitrogen, keep it at this temperature for 8 hours and then cool to room temperature naturally.Filter solids,Liquid vacuum distillation,Recover the solvent DMF,The product 5-chloro-2-fluoro-nitrobenzene 2.03g,The yield was 77.2%.

References:

Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.;Jiang Peng;Wang Qiang CN111848695, 2020, A Location in patent:Paragraph 0045-0047

FullText