5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE synthesis
- Product Name:5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE
- CAS Number:76510-61-7
- Molecular formula:C5H5IN2OS
- Molecular Weight:268.08
5751-20-2
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76510-61-7
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Yield:76510-61-7 97%
Reaction Conditions:
with N-iodo-succinimide in chloroform at 70; for 2 h;
Steps:
I.2 Step 2: 5-iodo-2-(methylthio')pyrimidin-4(3H)-one (3)
Step 2: 5-iodo-2-(methylthio')pyrimidin-4(3H)-one (3) To a solution of 2-(methylthio)pyrimidin-4(3H)-one (2) (4.74 g, 33.3 mmol) in chloroform (45 mL), NIS (8.25 g, 36.7 mmol) was added. The solution was heated to 70 °C for 2 hours. The mixture was concentrated under reduced pressure. EtOAc was added and the organics were washed with water, filtered and dried to give the title compound (8.8 g, 97%) as a white solid. NMR (CD3OD) δ 8.30 (s, 1H), 2.45 (s, 3H); LCMS (Condition B): 1.43 min, 269 (M+H).
References:
WO2014/58685,2014,A1 Location in patent:Page/Page column 41; 42
6328-58-1
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