N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine synthesis
- Product Name:N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine
- CAS Number:93102-05-7
- Molecular formula:C13H23NOSi
- Molecular Weight:237.41
50-00-0
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![N-[(Trimethylsilyl)methyl]benzylamine](/CAS/GIF/53215-95-5.gif)
53215-95-5
145 suppliers
$11.00/1g
93102-05-7
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$6.00/1g
Yield:93102-05-7 97.5%
Reaction Conditions:
Stage #1: formaldehyd;N-(trimethylsilylmethyl)benzylamine in water at 0;
Stage #2: with potassium carbonate in water at 20; for 2 h;
Steps:
Intermediate P16: N-Benzyl-1 -methoxy-N-[(trimethylsilyl)methyl]methanamine
To the solution of formaldehyde (37%, 16.816 g, 207.19 mmol) at 0°C N-benzylo- 1 -(trimethylsilyl)methanamine (Intermediate P15, 28.588 g, 144.89 mmol) was added dropwise. To the mixture solid potassium carbonate (16.182 g, 115.91 mmol) was added and the whole was stirred at room temperature for 2 hours. Water (50 ml) was added and the mixture was extracted with diethyl ether (2 x 50 ml). Organic layer was washed with brine and dried over sodium sulphate. Solvent and drying agent were removed to obtain 33.551 g of the title product in the form of a yellow oil (yield 97.5%). 1H NMR (300 MHz, CDCl3): δ 7.35 - 7.18 (m, 5H), 3.99 (s, 2H), 3.75 (s, 2H), 3.22 (s, 3H), 2.18 (s, 2H), 0.13 (s, 9H).
References:
WO2014/24125,2014,A1 Location in patent:Page/Page column 24-25
67-56-1
733 suppliers
$9.00/25ml
50-00-0
842 suppliers
$10.00/25g
53215-95-5
145 suppliers
$11.00/1g
93102-05-7
294 suppliers
$6.00/1g
67-56-1
733 suppliers
$9.00/25ml
53215-95-5
145 suppliers
$11.00/1g
93102-05-7
294 suppliers
$6.00/1g
53215-95-5
145 suppliers
$11.00/1g
107-30-2
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93102-05-7
294 suppliers
$6.00/1g