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ChemicalBook CAS DataBase List Propionamide

Propionamide synthesis

14synthesis methods
-

Yield:79-05-0 87%

Reaction Conditions:

with ammonia in water at 20; for 0.5 h;

Steps:

1.15.a
Intermediate 15: 3-Ethyl-5-formyl- V V-dimethyl-4H-l,2,4-triazole-4-sulfonamide Step a: propionamide[0489] A mixture of propionyl chloride (5.0 ml, 57.5 mmol) and NH3.H2O (80.0 mL) was stirred at room temperature for 0.5 h. The mixture was concentrated and the residue was treated with ethanol and filtered. The filtrate was concentrated to afford 3.44 g of the title compound (87% yield).

References:

ZENOBIA THERAPEUTICS, INC.;BOUNAUD, Pierre-Yves;NIENABER, Vicki;STEENSMA, Ruo, W.;LOWE, John, A., III WO2012/178015, 2012, A2 Location in patent:Page/Page column 123-124

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