ChemicalBook CAS DataBase List Testosterone undecanoate

Testosterone undecanoate synthesis

6synthesis methods

Product Name:Testosterone undecanoate
CAS Number:5949-44-0
Molecular formula:C30H48O3
Molecular Weight:456.71

17746-05-3
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58-22-0 Synthesis

58-22-0
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$19.00/1 mg

5949-44-0
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$810.00/5g

Yield:5949-44-0 96%

Reaction Conditions:

with pyridine in N,N-dimethyl-formamide at 0 - 20; for 1 h;Inert atmosphere;Solvent;Reagent/catalyst;

Steps:

1 Example 1
First, under nitrogen, 5g of testosterone and 25ml of N,N-dimethylformamide (DMF, solvent), as well as 5ml pyridine (pyridine, base) are well-mixed, and then, at 0-10 deg.C was added 4.6ml undecanoyl chloride, and react at room temperature for 1 hour. After completion of the reaction, 5ml of water was added and stirred for 1 hour and the precipitated product was filtered, and then rinsed under aqueous acetone and the product dried in vacuo at room temperature after to obtain 7.6g of testosterone undecyl acid, yield 96%, HPLC: 98.26%. And then the, re-crystallization step is undecyl Testosterone 120g 480ml of acetone was added and stirred until the whole solution, followed by addition of 180ml of water and stirred for 0.5 hours, filtered and washed with an aqueous solution of acetone and run through again after crystallization resulting undecyl acid testosterone S crystalline (Form S),

References:

Everlight Chemical Industrial Corp.;Shi, Yafang;Tsai, Chia-Chung;Yao, Chi-Hsiang CN105732754, 2016, A Location in patent:Paragraph 0024; 0025; 0026; 0027; 0028

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17746-05-3
135 suppliers
$6.00/1g