1010411-21-8
中文名称
GSK369796
英文名称
GSK369796
CAS
1010411-21-8
分子式
C20H24Cl3N3O
分子量
428.783
MOL 文件
1010411-21-8.mol
更新日期
2024/05/10 15:23:28
1010411-21-8 结构式
基本信息
中文别名
GSK369796二盐酸盐化合物GSK369796 DIHYDROCHLORIDE
2-((叔丁基氨基)甲基)-5-((7-氯喹啉-4-基)氨基)苯酚 二盐酸盐
英文别名
CS-2373GSK369796
GSK369796 HCL
GSK369796 2HCl
N-tert-butylisoquine
GSK 369796
GSK-369796
GSK369796 Dihydrochloride
GSK369796 (GSK-369796, GSK 369796)
5-[(7-Chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]phenol Hydrochloride
Phenol, 5-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-, hydrochloride
所属类别
生物化工：激动剂抑制剂物理化学性质
储存条件Inert atmosphere,Room Temperature
溶解度DMSO:100.0(Max Conc. mg/mL);233.22(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);116.61(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);116.61(Max Conc. mM)
形态固体
GSK369796价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-12082A | GSK369796 GSK369796 Dihydrochloride | 1010411-21-8 | 2mg | 1100元 |
| 2024/04/30 | HY-12082A | GSK369796 GSK369796 Dihydrochloride | 1010411-21-8 | 10mM * 1mLin DMSO | 1509元 |
| 2024/04/30 | HY-12082A | GSK369796 GSK369796 Dihydrochloride | 1010411-21-8 | 5mg | 1600元 |
常见问题列表
生物活性
GSK369796 Dihydrochloride (N-tert-butylisoquine)是 hERG potassium ion channel 重极化的抑制剂，其IC50值为7.5 μM。GSK369796 Dihydrochloride 是一种经济实惠且有效的4-氨基喹啉抗疟药。靶点
| Target | Value |
|
hERG
(Cell-free assay) | 7.5 μM |
体外研究
In vitro , GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC 50 s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC 50 of 7.5±0.8 μM.
体内研究
In vivo , GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED 50 and ED 90 of 2.8 and 4.7 mg/kg, respectively.