帕利伐米
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- CAS号:
- 31645-39-3
- 英文名:
- Palifosfamide
- 英文别名:
- Ipam;ZIO-201;Nsc 297900;ZIO-201, >98%;palifosfamide;Ifosforamide mustard;Isophosphamide mustard;Palifosfamide (ZIO-201);Abbreviation: IPM-lysine;isophosphoramide mustard-lysine
- 中文名:
- 帕利伐米
- 中文别名:
- 帕利伐米;帕利伐米, >98%;N,N'-双(2-氯乙基)二氨基膦酸
- CBNumber:
- CB11011411
- 分子式:
- C4H11Cl2N2O2P
- 分子量:
- 221.02
- MOL File:
- 31645-39-3.mol
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帕利伐米化学性质
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熔点:
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106-107 ºC
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沸点:
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341.5±52.0 °C(Predicted)
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密度:
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1.411
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储存条件:
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Store at -20°C, protect from light, stored under nitrogen
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溶解度:
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≥22.1 mg/mL in DMSO; insoluble in EtOH; ≥19.4 mg/mL in H2O with gentle warming and ultrasonic
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形态:
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Powder
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酸度系数(pKa):
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0.79±0.50(Predicted)
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InChI:
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InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
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InChIKey:
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BKCJZNIZRWYHBN-UHFFFAOYSA-N
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SMILES:
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P(NCCCl)(NCCCl)(O)=O
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CAS 数据库:
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31645-39-3
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帕利伐米性质、用途与生产工艺
帕利伐米（IPM）是环磷酰胺（CPA）的常见代谢产物。帕利伐米被认为是CPA表现出的至少一部分抗肿瘤活性的原因。直接使用帕利伐米作为抗癌剂的努力未获成功，部分原因是该化合物的不稳定性。已经合成了帕利伐米并且已经对该化合物进行了初步的生物学评估，但遗憾的是帕利伐米太不稳定而不能被分离并用于人类治疗。
Palifosfamide (ZIO-201, Isophosphamide mustard)是新型的DNA烷化剂，是异环磷酰胺（ifosfamide）的活性代谢产物，具有抗肿瘤活性。
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines
in vitro
. The
IC
50
ranges from 2.25 ro 6.75 μM for most cell lines except OS222 (IC
50
=31.5 μM).
Tumor growth inhibition is seen in both OS31 and OS33 xenografts and the RMS xenograft resulting in a significant difference in event-free survival between the control and the treated groups. Differential gene expression of ALDH3A1 but not ALDH1A1 is noted in the OS31 xenograft. Stabilized palifosfamide administered to mice suppresses MX-1 tumor growth by greater than 80% with 17% complete antitumor responses. Oral bioavailability in rats is 48-73% of parenteral administration, and antitumor activity in mice is equivalent by both routes. Treatment with palifosfamide-tris combined with docetaxelor doxorubicin at optimal regimens results in complete tumor regression in 62-75% of mice.
帕利伐米
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-14798 | Palifosfamide | | 1 mg | 680元 |
| 2024/04/30 | S5840 | 帕利伐米
Palifosfamide | 31645-39-3 | 2mg | 1204.8元 |
帕利伐米
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帕利伐米国内生产厂家
31645-39-3, 帕利伐米 相关搜索:
- 药靶配体
- 药物API与中间体
- 细胞周期
- 有机原料
- C4H11Cl2N2O2P
- 帕利伐米, >98%
- 帕利伐米
- N,N'-双(2-氯乙基)二氨基膦酸
- 31645-39-3
- ZIO 201,inhibit,Palifosfamide,ZIO201,DNA Alkylator/Crosslinker,Inhibitor,Drug Metabolite,IPM
- Palifosfamide (ZIO-201)
- ISOPHOSPHORAMIDE MUSTARD-LYSINE;ABBREVIATION: IPM-LYSINE;ZIO-201.
- isophosphoramide mustard-lysine
- Abbreviation: IPM-lysine
- ZIO-201, >98%
- ZIO-201
- Nsc 297900
- N1,N2-Bis(2-chloroethyl)phosphoric acid diamide
- N,N'-Bis(2-chloroethyl)phosphorodiamidic acid
- palifosfamide
- Isophosphamide mustard
- N,N'-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDATE
- N,N'-Di-(2-chloroethyl)phosphorodiamidic acid
- Ipam
- Ifosforamide mustard