马来酸哌克昔林
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- CAS号:
- 6724-53-4
- 英文名:
- PERHEXILINE MALEATE SALT
- 英文别名:
- Pexid;WSM-3978;WSM 3978G;perhexilinemaleate;perhexilene maleate;rac Perhexiline Maleate;PERHEXILINE MALEATE SALT;PERHEXILINE MALEATE SALT USP/EP/BP;2-(2,2-dicyclohexylethyl)piperidinemaleate;2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1)
- 中文名:
- 马来酸哌克昔林
- 中文别名:
- 马来酸哌西林;马来酸哌克昔林;哌克昔林 马来酸盐;RAC 马来酸哌克昔林;2-(2,2-二环己基乙基)哌啶 马来酸盐;肉碱棕榈酰转移酶1抑制剂(PERHEXILINE MALEATE)
- CBNumber:
- CB1464993
- 分子式:
- C23H39NO4
- 分子量:
- 393.56
- MOL File:
- 6724-53-4.mol
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马来酸哌克昔林化学性质
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熔点:
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181-183°C
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥5mg/mL
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形态:
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powder
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颜色:
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white to tan
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马来酸哌克昔林性质、用途与生产工艺
Perhexiline maleate 是一种有效的 carnitine palmitoyltransferase 1 (CPT1) 的抑制剂，对大鼠心脏CPT1和肝脏CPT1的IC50值分别为77 μM和148 μM。
| Target | Value |
rat heart CPT1
(Cell-free assay)
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77 μM
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rat liver CPT1
(Cell-free assay)
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148 μM
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At 24, 48 and 72 h of treatment with 0.01 and 1 μM of Perhexiline , NDM29 ncRNA expression level in SH-SY5Y cells is progressively increased, reaching a peak after 48 hours of treatment. Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the
in vitro
clonogenic potential of NB cells.
The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. Perhexiline favors NB cell transition to differentiated phenotype.
马来酸哌克昔林
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1334A | Perhexiline maleate | | 1 mg | 454元 |
| 2024/04/30 | HY-B1334A | 马来酸哌克昔林
Perhexiline maleate | 6724-53-4 | 5mg | 1000元 |
马来酸哌克昔林
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6724-53-4, 马来酸哌克昔林 相关搜索:
- THENYLENE
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- 高端化学
- 医药原料
- 细胞生物学试剂
- PEM - POLA
- Analytical Chromatography Product Catalog
- Alphabetic
- Analytical Standards
- C19H35NC4H4O4
- C23H39NO4
- RAC 马来酸哌克昔林
- 哌克昔林 马来酸盐
- 2-(2,2-二环己基乙基)哌啶 马来酸盐
- 肉碱棕榈酰转移酶1抑制剂(PERHEXILINE MALEATE)
- 马来酸哌西林
- 马来酸哌克昔林
- 6724-53-4
- Perhexiline maleate,inhibit,Perhexiline,Mitochondrial Metabolism,Inhibitor
- PERHEXILINE MALEATE SALT USP/EP/BP
- WSM 3978G
- 2-(2,2-dicyclohexylethyl)-piperidine, 2Z-butenedioate
- PERHEXILINE MALEATE SALT
- 2-[2,2-DICYCLOHEXYLETHYL]PIPERIDINE MALEATE SALT
- 2-(2,2-dicyclohexylethyl)piperidinium hydrogen maleate
- rac Perhexiline Maleate
- WSM-3978
- Pexid
- perhexilene maleate
- perhexilinemaleate
- 2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1)
- 2-(2,2-dicyclohexylethyl)piperidinemaleate