螺哌丙苯
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- CAS号:
- 510-74-7
- 英文名:
- AMI-193
- 英文别名:
- R 5808;AMI-193;spiramide;Fluroxyspiramine;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
- 中文名:
- 螺哌丙苯
- 中文别名:
- 螺哌丙苯;螺拉米特;AMI-193,D2样拮抗剂
- CBNumber:
- CB2728009
- 分子式:
- C22H26FN3O2
- 分子量:
- 383.46
- MOL File:
- 510-74-7.mol
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螺哌丙苯化学性质
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熔点:
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176 - 179°C
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储存条件:
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Store at RT
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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White solid.
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颜色:
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Off-White to Pale Yellow
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螺哌丙苯性质、用途与生产工艺
Spiramide (AMI-193) 是一种有效和选择性的 5-HT2 和 dopamine D2 受体拮抗剂，Ki 值分别为 2 nM 和 3 nM。Spiramide 对 5-HT2 受体的选择性与 5-HT1C 受体 (Ki=4300 nM) 相比大于 2000 倍。Spiramide 具有抗精神病活性。
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5-HT
2
Receptor
2 nM (Ki)
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D
2
Receptor
3 nM (Ki)
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5-HT
1A
Receptor
50 nM (Ki)
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D
1
Receptor
2530 nM (Ki)
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5-HT
1C
Receptor
4300 nM (Ki)
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Spiramide retains affinity for 5-HT
1A
sites (K
i
=50 nM) and also binds at dopamine D2 sites (K
i
=3 nM), but possesses low affinity for dopamine D1 sites (K
i
=2530 nM).
AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination.
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments.
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion).
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Animal Model:
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Adult male squirrel monkeys (850-1300 g)
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Dosage:
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0.003, 0.01 mg/kg
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Administration:
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I.m. on Tuesday, Wednesday, and Thursday the following week
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Result:
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Decreased the response rate.
The rate-decreasing effects were reversed by cocaine.
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螺哌丙苯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100971 | 螺哌丙苯
Spiramide | 510-74-7 | 5mg | 800元 |
| 2024/04/30 | HY-100971 | 螺哌丙苯
Spiramide | 510-74-7 | 10mM * 1mLin DMSO | 880元 |
510-74-7, 螺哌丙苯 相关搜索:
- Serotonin receptor
- 合成有机化合物配体
- C22H26FN3O2
- AMI-193,D2样拮抗剂
- 螺哌丙苯
- 螺拉米特
- 510-74-7
- 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
- R 5808
- Fluroxyspiramine
- 1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one
- spiramide
- AMI-193
- 8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE
- 8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE