螺哌丙苯
中文名称 | 螺哌丙苯 |
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中文同义词 | 螺拉米特;螺哌丙苯;AMI-193,D2样拮抗剂 |
英文名称 | AMI-193 |
英文同义词 | 8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;AMI-193;spiramide;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;Fluroxyspiramine;R 5808;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl- |
CAS号 | 510-74-7 |
分子式 | C22H26FN3O2 |
分子量 | 383.46 |
EINECS号 | |
相关类别 | Serotonin receptor |
Mol文件 | 510-74-7.mol |
结构式 |
螺哌丙苯 性质
熔点 | 176 - 179°C |
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储存条件 | Store at RT |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 白色固体。 |
颜色 | 灰白色至浅黄色 |
5-HT 2 Receptor 2 nM (Ki) |
D 2 Receptor 3 nM (Ki) |
5-HT 1A Receptor 50 nM (Ki) |
D 1 Receptor 2530 nM (Ki) |
5-HT 1C Receptor 4300 nM (Ki) |
Spiramide retains affinity for 5-HT 1A sites (K i =50 nM) and also binds at dopamine D2 sites (K i =3 nM), but possesses low affinity for dopamine D1 sites (K i =2530 nM).
AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination.
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments.
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion).
Animal Model: | Adult male squirrel monkeys (850-1300 g) |
Dosage: | 0.003, 0.01 mg/kg |
Administration: | I.m. on Tuesday, Wednesday, and Thursday the following week |
Result: |
Decreased the response rate.
The rate-decreasing effects were reversed by cocaine. |