PF 04995274
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- CAS号:
- 1331782-27-4
- 英文名:
- PF 04995274
- 英文别名:
- PF 04995274;PF04995274;PF 04995274;PF-04995274 >=98% (HPLC);4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol;2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-;Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
- 中文名:
- PF 04995274
- 中文别名:
- 化合物PF-04995274
- CBNumber:
- CB42668576
- 分子式:
- C23H32N2O6
- 分子量:
- 432.51
- MOL File:
- 1331782-27-4.mol
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PF 04995274化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM)
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形态:
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A crystalline solid
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PF 04995274性质、用途与生产工艺
PF-04995274 (PF-4995274) 是一种有效的、高亲和力的 serotonin 4 receptor (5-HT4R) 的口服活性部分激动剂,对人类5-HT4A/4B/4D/4E的EC50值分别为0.47 nM、0.36 nM、0.37 nM和0.26 nM。对于大鼠5-HT4S/4L/4E的EC50值分别为0.59 nM、0.65 nM和0.62 nM。PF-04995274 具有大脑渗透性,可用于与阿尔茨海默氏病相关的认知障碍。
Target | Value |
human 5-HT4E
(Cell-free assay)
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0.26 nM(EC50)
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human 5-HT4B
(Cell-free assay)
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0.36 nM(EC50)
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human 5-HT4D
(Cell-free assay)
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0.37 nM(EC50)
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human 5-HT4A
(Cell-free assay)
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0.47 nM(EC50)
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rat 5-HT4S
(Cell-free assay)
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0.59 nM(EC50)
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PF 04995274
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-18137 | PF 04995274 PF-04995274 | 1331782-27-4 | 1mg | 500元 |
2024/04/30 | HY-18137 | PF 04995274 PF-04995274 | 1331782-27-4 | 10mM * 1mLin DMSO | 761元 |
1331782-27-4, PF 04995274 相关搜索:
- 合成有机化合物配体
- 化合物PF-04995274
- 1331782-27-4
- Inhibitor,5-HT4,5-hydroxytryptamine Receptor,behavior,Alzheimer′s disease,PF-04995274,inhibit,PF04995274,Serotonin Receptor,5-HT Receptor,Stress-induced,PF 04995274,depressive-like
- 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
- PF04995274;PF 04995274
- 2H-Pyran-4-ol, tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-
- PF-04995274 >=98% (HPLC)
- PF 04995274