GSK369796
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- CAS号:
- 1010411-21-8
- 英文名:
- GSK369796
- 英文别名:
- CS-2373;GSK369796;GSK369796 HCL;GSK369796 2HCl;N-tert-butylisoquine;GSK 369796; GSK-369796;GSK369796 Dihydrochloride;GSK369796 (hydrochloride);GSK369796 (GSK-369796, GSK 369796);5-[(7-Chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]phenol Hydrochloride
- 中文名:
- GSK369796
- 中文别名:
- GSK369796二盐酸盐;化合物GSK369796 DIHYDROCHLORIDE;2-((叔丁基氨基)甲基)-5-((7-氯喹啉-4-基)氨基)苯酚 二盐酸盐
- CBNumber:
- CB62524915
- 分子式:
- C20H24Cl3N3O
- 分子量:
- 428.78306
- MOL File:
- 1010411-21-8.mol
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GSK369796化学性质
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);233.22(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);116.61(Max Conc. mM)-
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形态:
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A solid
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GSK369796性质、用途与生产工艺
GSK369796 Dihydrochloride (N-tert-butylisoquine)是 hERG potassium ion channel 重极化的抑制剂，其IC50值为7.5 μM。GSK369796 Dihydrochloride 是一种经济实惠且有效的4-氨基喹啉抗疟药。
| Target | Value |
hERG
(Cell-free assay)
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7.5 μM
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In vitro
, GSK369796 Dihydrochloride can inhibit the growth of
Plasmodium falciparum
strains 3D7c, HB3c and K1d, with IC
50
s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC
50
of 7.5±0.8 μM.
In vivo
, GSK369796 Dihydrochloride can inhibit the growth of
Plasmodium berghei
ANKA with ED
50
and ED
90
of 2.8 and 4.7 mg/kg, respectively.
GSK369796
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12082A | GSK369796
GSK369796 Dihydrochloride | 1010411-21-8 | 2mg | 1100元 |
| 2024/04/30 | HY-12082A | GSK369796
GSK369796 Dihydrochloride | 1010411-21-8 | 10mM * 1mLin DMSO | 1509元 |
1010411-21-8, GSK369796 相关搜索:
- 药靶配体
- 2-((叔丁基氨基)甲基)-5-((7-氯喹啉-4-基)氨基)苯酚 二盐酸盐
- GSK369796二盐酸盐
- 化合物GSK369796 DIHYDROCHLORIDE
- 1010411-21-8
- GSK369796 (hydrochloride)
- inhibit,GSK 369796,GSK369796,Inhibitor,GSK369796 Dihydrochloride,GSK-369796,GSK-369796 Dihydrochloride,Parasite,Potassium Channel,KcsA
- GSK369796 2HCl
- GSK369796 HCL
- 5-[(7-Chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]phenol Hydrochloride
- GSK369796 (GSK-369796, GSK 369796)
- CS-2373
- N-tert-butylisoquine
- GSK 369796; GSK-369796
- Phenol, 5-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-, hydrochloride
- GSK369796 Dihydrochloride
- GSK369796