GSK369796
| 中文名称 | GSK369796 |
|---|---|
| 中文同义词 | 化合物GSK369796 DIHYDROCHLORIDE;GSK369796二盐酸盐;2-((叔丁基氨基)甲基)-5-((7-氯喹啉-4-基)氨基)苯酚 二盐酸盐 |
| 英文名称 | GSK369796 |
| 英文同义词 | GSK369796;GSK369796 Dihydrochloride;Phenol, 5-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-, hydrochloride;GSK 369796; GSK-369796;N-tert-butylisoquine;CS-2373;GSK369796 (GSK-369796, GSK 369796);5-[(7-Chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]phenol Hydrochloride |
| CAS号 | 1010411-21-8 |
| 分子式 | C20H24Cl3N3O |
| 分子量 | 428.78306 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1010411-21-8.mol |
| 结构式 |  |
GSK369796 性质
| 储存条件 | Inert atmosphere,Room Temperature |
|---|---|
| 溶解度 | DMSO:100.0(最大浓度 mg/mL);233.22(最大浓度 mM) 水:50.0(最大浓度 mg/mL);116.61(最大浓度 mM) |
| 形态 | 固体 |
GSK369796 Dihydrochloride (N-tert-butylisoquine)是 hERG potassium ion channel 重极化的抑制剂，其IC50值为7.5 μM。GSK369796 Dihydrochloride 是一种经济实惠且有效的4-氨基喹啉抗疟药。
| Target | Value |
|
hERG
(Cell-free assay) | 7.5 μM |
In vitro , GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC 50 s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC 50 of 7.5±0.8 μM.
In vivo , GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED 50 and ED 90 of 2.8 and 4.7 mg/kg, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12082A | GSK369796 GSK369796 Dihydrochloride | 1010411-21-8 | 2mg | 1100元 |
| 2024/04/30 | HY-12082A | GSK369796 GSK369796 Dihydrochloride | 1010411-21-8 | 10mM * 1mLin DMSO | 1509元 |