N-乙酰基神经鞘氨醇
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- CAS号:
- 3102-57-6
- 英文名:
- C2 CERAMIDE
- 英文别名:
- N-ACETYLSPHINGOSINE;N-ACETYL-D-SPHINGOSINE;N-ETHANOYL-D-ERYTHRO-SPHINGOSINE;CERAMIDE C2;C2 CERAMIDE;C2:0 CERAMIDE;TOC Ceramide;ACETYL CERAMIDE;C14 SPHINGOID BASE;N-Acetylsphigosine
- 中文名:
- N-乙酰基神经鞘氨醇
- 中文别名:
- N-乙酰鞘氨醇;C2 神经酰胺;化合物 T22644;N-乙酰基神经鞘氨醇;N-乙酰基-D-鞘氨醇;N-乙酰基-D-神经鞘氨醇;N-[(1S,2R,3E)-2-羟基-1-(羟甲基)-3-庚烯-1-基]-乙酰胺
- CBNumber:
- CB8342539
- 分子式:
- C20H39NO3
- 分子量:
- 341.53
- MOL File:
- 3102-57-6.mol
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N-乙酰基神经鞘氨醇化学性质
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熔点:
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93-96 °C
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沸点:
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477.13°C (rough estimate)
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密度:
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1.0283 (rough estimate)
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折射率:
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1.5614 (estimate)
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储存条件:
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−20°C
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溶解度:
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DMSO: soluble
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酸度系数(pKa):
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13.50±0.20(Predicted)
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形态:
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powder
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颜色:
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white
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稳定性:
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Moisture Sensitive
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N-乙酰基神经鞘氨醇性质、用途与生产工艺
C2 Ceramide (Ceramide 2) 是一种角质层的主要脂质，也是一种蛋白质磷酸酶 1 (PP1) 的激活剂。C2 Ceramide 还可激活 PP2A 和神经酰胺激活的蛋白磷酸酶 (CAPP)。C2 Ceramide 可诱导细胞分化和凋亡 (apoptosis)，抑制线粒体呼吸链复合物 III (mitochondrial respiratory chain complex III)。C2 Ceramide 是一种皮肤调理剂，可保护表皮屏障免受水分流失。
Protein phosphatase 1
PP2A
Ceramide-activated protein phosphatase (CAPP)
Apoptosis
Mitochondrial respiratory chain complex III
C2 Ceramide (5 nM-200 µM; 24 hours; primary mouse osteoblasts) treatment (≤500 nM) promots osteoblast viability, whilst concentrations ≥2 µM significantly reduces osteoblast viability in a dose- and time-dependent manner.
C2 Ceramide increases cytoplasmic histone-associated DNA fragments by 5.7- and 11.2-fold at 50 µM and 100 µM C2 Ceramide concentrations respectively in osteoblasts. At these higher concentrations, C2 Ceramide is a potent inducer of apoptosis in osteoblasts.
C2 Ceramide up-regulates mRNA expression of angiogenic genes in human dental pulp cells (HDPCs) and increases the migration and capillary tube formation of endothelial cells, whereas PP1 small interfering RNA shows opposite effects. Human dental pulp cells (HDPCs) increases levels of bone morphogenetic protein 2, phosphorylation of Smad 1/5/8, and mRNA expression of runt-related transcription factor 2 and osterix.
Cell Viability Assay
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Cell Line:
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Primary mouse osteoblasts
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Concentration:
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5 nM-200 µM
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Incubation Time:
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24 hours
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Result:
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Murine osteoblasts demonstrated a dose-dependent increase in their survival rate when exposed to low concentrations of 5-500 n M. Increasing concentrations of 20-200µM caused a dose-dependent decrease in mitochondrial succinate dehydrogenase activity and osteoblast survival.
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The PP1 activator C2 Ceramide increases alkaline phosphatase activity, mineralizes nodule formation, and mRNA expression of dentin matrix protein 1 and dentin sialophosphoprotein. In contrast, knockdown by PP1 small interfering RNA inhibits odontoblastic differentiation.
N-乙酰基神经鞘氨醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101180 | C2 Ceramide | | 1 mg | 400元 |
| 2024/04/30 | HY-101180 | C2 Ceramide | | 10 mg | 2170元 |
3102-57-6, N-乙酰基神经鞘氨醇 相关搜索:
- Lipid signaling
- Protein Kinase Inhibitors and Activators
- Inhibitors
- Glycerols
- Fatty Acid Derivatives & Lipids
- Activators
- Mixed Fatty Acids
- 小分子
- 生化试剂
- Cancer Research
- Antitumor Agents
- Anti-Proliferative Agents
- BioChemical
- 3101-57-6
- 7344-2-7
- 3102-57-5
- N-乙酰基-D-鞘氨醇
- 化合物 T22644
- N-乙酰鞘氨醇
- N-[(1S,2R,3E)-2-羟基-1-(羟甲基)-3-庚烯-1-基]-乙酰胺
- C2 神经酰胺
- N-乙酰基-D-神经鞘氨醇
- N-乙酰基神经鞘氨醇
- 3102-57-6
- C2 Ceramide,C-2 Ceramide
- N-ETHANOYL-D-ERYTHRO-SPHINGOSINE
- N-ACETYL-D-SPHINGOSINE
- N-ACETYLSPHINGOSINE
- N-Acetylsphigosine
- D-erythro-Sphingosine, N-Acetyl- - CAS 3102-57-6 - Calbiochem
- Acetamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-
- C2 Ceramide (d18:1/2:0)
- (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol
- N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxyMethyl)-3-heptadecen-1-yl]acetaMide
- Acetyl ceramide, C2 ceramide
- TOC Ceramide
- N-Ethanoyl-D-sphingosine
- D-erythro-Sphingoshine, N-Acetyl-
- (D-erythro-N-Acetylsphingosine)
- N-Ethanoyl-D-erythro-sphingosine, synthetical
- N-ETHANOYL-D-ERYTHRO-SPHINGOSINE SYNTHE TICAL 99+%
- ACETYL CERAMIDE
- D-ERYTHRO-SPHINGOSINE, N-ACETYL-
- CERAMIDE C2
- C2 CERAMIDE OF D-ERYTHRO-C14-SPHINGOSINE
- C2 CERAMIDE
- C2-D-ERYTHRO-CERAMIDE
- C2:0 CERAMIDE
- C14 SPHINGOID BASE
- N-ACETYLSPHINGOSINE, D-ERYTHRO
- N-ACETYL-D-ERYTHRO-SPHINGOSINE