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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
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- CAS号:
- 65836-72-8
- 英文名:
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- 英文别名:
- DKM 2-93;Brn 2857211;CHEMBRDG-BB 9070724;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
- 中文名:
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- 中文别名:
- 2-氯-N-((3;4-二甲氧苯基)甲基)乙酰胺;UBA5抑制剂(DKM 2-93);2-氯-N-(3,4-二甲氧基苄基)乙酰胺;2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺;2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺;乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-
- CBNumber:
- CB9796621
- 分子式:
- C11H14ClNO3
- 分子量:
- 243.69
- MOL File:
- 65836-72-8.mol
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE化学性质
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熔点:
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116-118 °C(Solv: carbon tetrachloride (56-23-5))
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沸点:
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425.7±45.0 °C(Predicted)
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密度:
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1.194±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 150 mg/mL (615.54 mM)
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酸度系数(pKa):
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13.42±0.46(Predicted)
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE性质、用途与生产工艺
DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC
50
s of 90 and 30 μM, respectively.
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells
in vivo
in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
DKM 2-93 | 65836-72-8 | 50mg | 660元 |
| 2024/04/30 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
DKM 2-93 | 65836-72-8 | 10mM * 1mLin DMSO | 726元 |
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
生产厂家
65836-72-8, 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 相关搜索:
- 药靶配体
- 抑制剂
- 细胞生物学试剂
- 4-二甲氧苯基)甲基)乙酰胺
- 2-氯-N-((3
- UBA5抑制剂(DKM 2-93)
- 乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-
- 2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺
- 2-氯-N-(3,4-二甲氧基苄基)乙酰胺
- 2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺
- 65836-72-8
- E1 activating enzyme,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Inhibitor,DKM 2-93,Ubiquitin conjugating enzyme,Ubiquitin ligase,inhibit,E3 ligating enzyme,E2 conjugating enzyme,DKM 293,DKM 2 93
- DKM 2-93
- 2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
- 2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
- N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
- N-(Dimethoxy-3,4 benzyl)-chloroacetamide
- Brn 2857211
- Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
- 2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
- CHEMBRDG-BB 9070724
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE